Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults
Highlights • We examine the relationship between variation in CRHR1 and post-hurricane PTSD. • We found that rs12938031 and rs4792887 remained associated with PTSD symptoms. • This is the first study examining the association between CRHR1 and PTSD in adults. • Results justify additional research to...
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| Veröffentlicht in: | Journal of anxiety disorders 2013-10, Vol.27 (7), p.678-683 |
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| container_title | Journal of anxiety disorders |
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| creator | White, Simone Acierno, Ron Ruggiero, Kenneth J Koenen, Karestan C Kilpatrick, Dean G Galea, Sandro Gelernter, Joel Williamson, Vernell McMichael, Omari Vladimirov, Vladimir I Amstadter, Ananda B |
| description | Highlights • We examine the relationship between variation in CRHR1 and post-hurricane PTSD. • We found that rs12938031 and rs4792887 remained associated with PTSD symptoms. • This is the first study examining the association between CRHR1 and PTSD in adults. • Results justify additional research to characterize how CRHR1 relates to PTSD. • Identifying genetic variants is valuable for resource allocation post-trauma. |
| doi_str_mv | 10.1016/j.janxdis.2013.08.003 |
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Neuroses</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>CRHR1</subject><subject>Cyclonic Storms</subject><subject>Diagnosis</subject><subject>Disasters</subject><subject>Female</subject><subject>Genes</subject><subject>HPA axis</subject><subject>Humans</subject><subject>Hurricanes</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phenotypes</subject><subject>Pituitary-Adrenal System - physiopathology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Post-traumatic stress disorder</subject><subject>Posttraumatic stress disorder</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Corticotropin-Releasing Hormone - genetics</subject><subject>Stress Disorders, Post-Traumatic - epidemiology</subject><subject>Stress Disorders, Post-Traumatic - genetics</subject><subject>Symptoms</subject><subject>Trauma</subject><subject>Variants</subject><issn>0887-6185</issn><issn>1873-7897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkkFvEzEQhVcIREPhJ4B8QeKSMF7ba--lqIqAIlVCKnDiYLneCXXYtYNnN2r-PY4SIuACF_sw3zy9mTdV9ZzDggNvXq8Xaxfvu0CLGrhYgFkAiAfVjBst5tq0-mE1A2P0vOFGnVVPiNYAXEOjH1dntQStQYhZ9fWSKPngxpAiSyu2vLm64WzrcnBxJOZixzaJxjG7aSiQZzRmJGK0GzZjGoiFyO6mnIN3ERneFxg75rqpH-lp9WjlesJnx_-8-vLu7efl1fz64_sPy8vruS_exjnnXjjvNLpbwLpWHgVf8QabBn1rBFetlp3ysmlqBSA1r4UGVyoKJSopxXl1cdDdTLcDdh5jsdvbTQ6DyzubXLB_VmK4s9_S1kpu6laZIvDqKJDTjwlptEMgj31fZkoTWa4kb03Z43-gUrWqUUpCQdUB9TkRZVydHHGw-wzt2h4ztPsMLRhbMix9L34f59T1K7QCvDwCjrzrV9lFXzROnAEJ5SncmwOHZfnbgNmSDxg9diGjH22Xwj-tXPyl4PsQS9b9d9whrdOUY0nWcku1Bftpf3D7e-Oi3JqURvwEL5DStQ</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>White, Simone</creator><creator>Acierno, Ron</creator><creator>Ruggiero, Kenneth J</creator><creator>Koenen, Karestan C</creator><creator>Kilpatrick, Dean G</creator><creator>Galea, Sandro</creator><creator>Gelernter, Joel</creator><creator>Williamson, Vernell</creator><creator>McMichael, Omari</creator><creator>Vladimirov, Vladimir I</creator><creator>Amstadter, Ananda B</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QJ</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults</title><author>White, Simone ; Acierno, Ron ; Ruggiero, Kenneth J ; Koenen, Karestan C ; Kilpatrick, Dean G ; Galea, Sandro ; Gelernter, Joel ; Williamson, Vernell ; McMichael, Omari ; Vladimirov, Vladimir I ; Amstadter, Ananda B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-11c3aca7eab0e225ce31f16e66ec98315974d5c46625004712370a9835e4e5443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aetiology</topic><topic>Aftermath</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>CRHR1</topic><topic>Cyclonic Storms</topic><topic>Diagnosis</topic><topic>Disasters</topic><topic>Female</topic><topic>Genes</topic><topic>HPA axis</topic><topic>Humans</topic><topic>Hurricanes</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phenotypes</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Post-traumatic stress disorder</topic><topic>Posttraumatic stress disorder</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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| subjects | Adult and adolescent clinical studies Aetiology Aftermath Anxiety disorders. Neuroses Biological and medical sciences Cohort Studies CRHR1 Cyclonic Storms Diagnosis Disasters Female Genes HPA axis Humans Hurricanes Hypothalamo-Hypophyseal System - physiopathology Male Medical sciences Middle Aged Phenotypes Pituitary-Adrenal System - physiopathology Polymorphism, Single Nucleotide - genetics Post-traumatic stress disorder Posttraumatic stress disorder Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Corticotropin-Releasing Hormone - genetics Stress Disorders, Post-Traumatic - epidemiology Stress Disorders, Post-Traumatic - genetics Symptoms Trauma Variants |
| title | Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults |
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