Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults

Highlights • We examine the relationship between variation in CRHR1 and post-hurricane PTSD. • We found that rs12938031 and rs4792887 remained associated with PTSD symptoms. • This is the first study examining the association between CRHR1 and PTSD in adults. • Results justify additional research to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of anxiety disorders 2013-10, Vol.27 (7), p.678-683
Hauptverfasser:	White, Simone, Acierno, Ron, Ruggiero, Kenneth J, Koenen, Karestan C, Kilpatrick, Dean G, Galea, Sandro, Gelernter, Joel, Williamson, Vernell, McMichael, Omari, Vladimirov, Vladimir I, Amstadter, Ananda B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aetiology Aftermath Anxiety disorders. Neuroses Biological and medical sciences Cohort Studies CRHR1 Cyclonic Storms Diagnosis Disasters Female Genes HPA axis Humans Hurricanes Hypothalamo-Hypophyseal System - physiopathology Male Medical sciences Middle Aged Phenotypes Pituitary-Adrenal System - physiopathology Polymorphism, Single Nucleotide - genetics Post-traumatic stress disorder Posttraumatic stress disorder Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Corticotropin-Releasing Hormone - genetics Stress Disorders, Post-Traumatic - epidemiology Stress Disorders, Post-Traumatic - genetics Symptoms Trauma Variants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We examine the relationship between variation in CRHR1 and post-hurricane PTSD. • We found that rs12938031 and rs4792887 remained associated with PTSD symptoms. • This is the first study examining the association between CRHR1 and PTSD in adults. • Results justify additional research to characterize how CRHR1 relates to PTSD. • Identifying genetic variants is valuable for resource allocation post-trauma.
ISSN:	0887-6185 1873-7897
DOI:	10.1016/j.janxdis.2013.08.003