Experimental Evidence for Hydrogen-Bonded Network Proton Transfer in Bacteriorhodopsin Shown by Fourier-Transform Infrared Spectroscopy Using Azide as Catalyst

Experimental evidence for proton transfer via a hydrogen-bonded network in a membrane protein is presented. Bacteriorhodopsin's proton transfer mechanism on the proton uptake pathway between Asp-96 and the Schiff base in the M-to-N transition was determined. The slowdown of this transfer by rem...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1995-05, Vol.92 (11), p.4962-4966
Hauptverfasser: Le Coutre, Johannes, Tittor, Jorg, Oesterhelt, Dieter, Gerwert, Klaus
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Sprache:eng
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