Interaction between neonatal vitamin A supplementation and timing of measles vaccination: A retrospective analysis of three randomized trials from Guinea-Bissau

Highlights • Early measles vaccine and neonatal vitamin A supplementation may become policy in low-income countries. • Vaccines and vitamin A may interact. • In children who received early measles vaccine, neonatal vitamin A was associated with 5-fold higher overall mortality. • Implementation of bo...

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Veröffentlicht in:Vaccine 2014-09, Vol.32 (42), p.5468-5474
Hauptverfasser: Benn, Christine S, Martins, Cesario L, Fisker, Ane B, Diness, Birgitte R, Garly, May-Lill, Balde, Ibraima, Rodrigues, Amabelia, Whittle, Hilton, Aaby, Peter
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Sprache:eng
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Zusammenfassung:Highlights • Early measles vaccine and neonatal vitamin A supplementation may become policy in low-income countries. • Vaccines and vitamin A may interact. • In children who received early measles vaccine, neonatal vitamin A was associated with 5-fold higher overall mortality. • Implementation of both policies at the same time may lead to increased child mortality. • Co-packaging of child health interventions should be investigated for the effect on overall mortality.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.07.090