Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: changes in metabolic pathways

Lipid metabolism under chronic hypoxia (CH) has not received equal attention as intermittent hypoxia (IH). To determine the CH-induced changes in plasma and liver, as well as the mRNA and protein expression of two key enzymes in the triglyceride and cholesterol biosynthesis pathways, SREBP-1 (HMG-Co...

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Veröffentlicht in:	High altitude medicine & biology 2014-09, Vol.15 (3), p.388-395
Hauptverfasser:	Siques, Patricia, Brito, Julio, Naveas, Nelson, Pulido, Ruth, De la Cruz, Juan José, Mamani, Maribel, León-Velarde, Fabiola
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Blotting, Western Cholesterol - metabolism Chronic Disease Hematocrit Hemoglobins - metabolism Hydroxymethylglutaryl CoA Reductases - metabolism Hypoxia - etiology Hypoxia - metabolism Liver - enzymology Liver - metabolism Male Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Scientific Space life sciences Stearoyl-CoA Desaturase - metabolism Triglycerides - metabolism Up-Regulation
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Zusammenfassung:	Lipid metabolism under chronic hypoxia (CH) has not received equal attention as intermittent hypoxia (IH). To determine the CH-induced changes in plasma and liver, as well as the mRNA and protein expression of two key enzymes in the triglyceride and cholesterol biosynthesis pathways, SREBP-1 (HMG-CoA reductase) and SREBP-2 (SCD-1), we exposed adult male Wistar rats to CH (4600 m; n=15) for 30 days compared to normoxic rats (n=15). The CH rats exhibited weight loss (p
ISSN:	1527-0297 1557-8682
DOI:	10.1089/ham.2013.1134