Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors

Highlights • Different kainate receptor subunits confer distinct pharmacological properties. • In heteromeric receptors, agonist binding to either type of subunit can activate the channel. • Desensitization of GluK2/K5 heteromers requires occupancy of both subunits in a dimer.

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Veröffentlicht in:	Neuroscience 2014-10, Vol.278, p.70-80
Hauptverfasser:	Fisher, M.T, Fisher, J.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics GluK2 Kainate Receptor glutamate Glutamic Acid - physiology HEK293 Cells Humans kainate receptors Membrane Potentials - physiology mutagenesis Mutation Neurology patch-clamp Protein Subunits - genetics Protein Subunits - physiology Rats Receptors, Kainic Acid - genetics Receptors, Kainic Acid - physiology Recombinant Proteins
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Beschreibung
Zusammenfassung:	Highlights • Different kainate receptor subunits confer distinct pharmacological properties. • In heteromeric receptors, agonist binding to either type of subunit can activate the channel. • Desensitization of GluK2/K5 heteromers requires occupancy of both subunits in a dimer.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.009