Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the production of antibodies to self-nucleic acids, immune complex deposition, and tissue inflammation such as glomerulonephritis. Innate recognition of self-DNA and -RNA and the ensuing production of cytokines such as typ...

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Veröffentlicht in:	The Journal of experimental medicine 2014-09, Vol.211 (10), p.1969-1976
Hauptverfasser:	Sisirak, Vanja, Ganguly, Dipyaman, Lewis, Kanako L, Couillault, Coline, Tanaka, Lena, Bolland, Silvia, D'Agati, Vivette, Elkon, Keith B, Reizis, Boris
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Antinuclear - immunology Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Brief Definitive Report Crosses, Genetic Dendritic Cells - immunology Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene Dosage - genetics Interferon Type I - immunology Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Real-Time Polymerase Chain Reaction Statistics, Nonparametric Toll-Like Receptor 7 - metabolism Transcription Factor 4
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