Rapid and accurate T2 mapping from multi-spin-echo data using Bloch-simulation-based reconstruction

Purpose Quantitative T2‐relaxation‐based contrast has the potential to provide valuable clinical information. Practical T2‐mapping, however, is impaired either by prohibitively long acquisition times or by contamination of fast multiecho protocols by stimulated and indirect echoes. This work presents a novel postprocessing approach aiming to overcome the common penalties associated with multiecho protocols, and enabling rapid and accurate mapping of T2 relaxation values. Methods Bloch simulations are used to estimate the actual echo‐modulation curve (EMC) in a multi–spin‐echo experiment. Simulations are repeated for a range of T2 values and transmit field scales, yielding a database of simulated EMCs, which is then used to identify the T2 value whose EMC most closely matches the experimentally measured data at each voxel. Results T2 maps of both phantom and in vivo scans were successfully reconstructed, closely matching maps produced from single spin‐echo data. Results were consistent over the physiological range of T2 values and across different experimental settings. Conclusion The proposed technique allows accurate T2 mapping in clinically feasible scan times, free of user‐ and scanner‐dependent variations, while providing a comprehensive framework that can be extended to model other parameters (e.g., T1, B1+, B0, diffusion) and support arbitrary acquisition schemes. Magn Reson Med 73:809–817, 2015. © 2014 Wiley Periodicals, Inc.