Relationship of clinical and pathologic nodal staging in locally advanced breast cancer: current controversies in daily practice?

Systemic neo-adjuvant therapy plays a primary role in the management of locally advanced breast cancer. Without having any negative effect in overall survival, induction chemotherapy potentially assures a surgery approach in unresectable disease or a conservative treatment in technically resectable...

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Veröffentlicht in:Journal of clinical medicine research 2014-12, Vol.6 (6), p.409-413
Hauptverfasser: De Felice, Francesca, Musio, Daniela, Bulzonetti, Nadia, Raffetto, Nicola, Tombolini, Vincenzo
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Sprache:eng
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Zusammenfassung:Systemic neo-adjuvant therapy plays a primary role in the management of locally advanced breast cancer. Without having any negative effect in overall survival, induction chemotherapy potentially assures a surgery approach in unresectable disease or a conservative treatment in technically resectable disease and acts on a well-vascularized tumor bed, without the modifications induced by surgery. A specific issue has a central function in the neo-adjuvant setting: lymph nodes status. It still represents one of the strongest predictors of long-term prognosis in breast cancer. The discussion of regional radiation therapy should be a matter of debate, especially in a pathological complete response. Currently, the indication for radiotherapy is based on the clinical stage before the surgery, even for the irradiation of the loco-regional lymph nodes. Regardless of pathological down-staging, radiation therapy is accepted as standard adjuvant treatment in locally advanced breast cancer.
ISSN:1918-3003
1918-3011
DOI:10.14740/jocmr1908w