Separate and combined effects of the GABAA positive allosteric modulator diazepam and Δ9 -THC in humans discriminating Δ9 -THC
Highlights • Diazepam shares discriminative stimulus effects with Δ9 -THC in animals. • This study tested diazepam in humans trained to discriminate Δ9 -THC. • Diazepam did not substitute for the Δ9 -THC discriminative stimulus. • Diazepam did not alter the Δ9 -THC discrimination dose–response funct...
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| Veröffentlicht in: | Drug and alcohol dependence 2014-10, Vol.143, p.141-148 |
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| container_title | Drug and alcohol dependence |
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| creator | Lile, Joshua A Kelly, Thomas H Hays, Lon R |
| description | Highlights • Diazepam shares discriminative stimulus effects with Δ9 -THC in animals. • This study tested diazepam in humans trained to discriminate Δ9 -THC. • Diazepam did not substitute for the Δ9 -THC discriminative stimulus. • Diazepam did not alter the Δ9 -THC discrimination dose–response function. • GABAA has minimal involvement in the interoceptive effects of Δ9 -THC in humans. |
| doi_str_mv | 10.1016/j.drugalcdep.2014.07.016 |
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| ispartof | Drug and alcohol dependence, 2014-10, Vol.143, p.141-148 |
| issn | 0376-8716 1879-0046 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4167716 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Allosteric Regulation - drug effects Blood Pressure - drug effects Body Temperature - drug effects Cannabinoid Receptor Agonists - pharmacology Cardiovascular Diazepam - pharmacology Digit-symbol-substitution task Discrimination Learning - drug effects Dose-Response Relationship, Drug Dronabinol - pharmacology Drug discrimination Drug Interactions Drug Therapy, Combination Female GABA Modulators - pharmacology GABA-A Receptor Agonists - pharmacology Heart Rate - drug effects Humans Male Marijuana Marijuana Smoking - psychology Psychiatry Psychomotor Performance - drug effects Receptors, GABA-A - metabolism Repeated acquisition task Subjective effects Young Adult |
| title | Separate and combined effects of the GABAA positive allosteric modulator diazepam and Δ9 -THC in humans discriminating Δ9 -THC |
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