Separate and combined effects of the GABAA positive allosteric modulator diazepam and Δ9 -THC in humans discriminating Δ9 -THC

Highlights • Diazepam shares discriminative stimulus effects with Δ9 -THC in animals. • This study tested diazepam in humans trained to discriminate Δ9 -THC. • Diazepam did not substitute for the Δ9 -THC discriminative stimulus. • Diazepam did not alter the Δ9 -THC discrimination dose–response funct...

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Veröffentlicht in:	Drug and alcohol dependence 2014-10, Vol.143, p.141-148
Hauptverfasser:	Lile, Joshua A, Kelly, Thomas H, Hays, Lon R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allosteric Regulation - drug effects Blood Pressure - drug effects Body Temperature - drug effects Cannabinoid Receptor Agonists - pharmacology Cardiovascular Diazepam - pharmacology Digit-symbol-substitution task Discrimination Learning - drug effects Dose-Response Relationship, Drug Dronabinol - pharmacology Drug discrimination Drug Interactions Drug Therapy, Combination Female GABA Modulators - pharmacology GABA-A Receptor Agonists - pharmacology Heart Rate - drug effects Humans Male Marijuana Marijuana Smoking - psychology Psychiatry Psychomotor Performance - drug effects Receptors, GABA-A - metabolism Repeated acquisition task Subjective effects Young Adult
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Zusammenfassung:	Highlights • Diazepam shares discriminative stimulus effects with Δ9 -THC in animals. • This study tested diazepam in humans trained to discriminate Δ9 -THC. • Diazepam did not substitute for the Δ9 -THC discriminative stimulus. • Diazepam did not alter the Δ9 -THC discrimination dose–response function. • GABAA has minimal involvement in the interoceptive effects of Δ9 -THC in humans.
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2014.07.016