Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid

Protective Effect of Huoxiang Zhengqi Oral Liquid on Intestinal Mucosal Mechanical Barrier of Rats with Postinfectious Irritable Bowel Syndrome Induced by Acetic Acid

In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-10
Hauptverfasser: Yu, Lin-Zhong, Peng, Jiang-Li, Peng, Qiu-Xian, Liu, Wei, Liu, Yao, Hu, Jian-Lan
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
Care and treatment
Disease
Ethanol
Gastroenterology
Intestine
Irrigation (Medicine)
Irritable bowel syndrome
Medicine
Methods
Mucosa
Permeability
Pharmacology
Small intestine
Ultrastructure
Zonula occludens-1 protein
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Zusammenfassung:In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of ZO-1 and occludin were examined to investigate protective effect mechanisms of HXZQ on intestinal mucosa barrier and then present experimental support for its use for prevention and cure of PI-IBS.
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/218383