Refined Mapping of a Hypertension Susceptibility Locus on Rat Chromosome 12

Previously, we found that transferring 6.1 Mb of salt-sensitive (SS) chromosome 12 (13.4–19.5 Mb) onto the consomic SS-12 background significantly elevated mean arterial pressure in response to an 8% NaCl diet (178±7 versus 144±2 mm Hg; P

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Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-10, Vol.64 (4), p.883-890
Hauptverfasser:	Prisco, Sasha Z, Prokop, Jeremy W, Sarkis, Allison B, Yeo, Nan Cher, Hoffman, Matthew J, Hansen, Colin C, Jacob, Howard J, Flister, Michael J, Lazar, Jozef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - genetics Blood Pressure - physiology Chromosome Mapping - methods Chromosomes, Human, Pair 7 - genetics Chromosomes, Mammalian - genetics Gene Expression - drug effects Genetic Predisposition to Disease - genetics Humans Hypertension - etiology Hypertension - genetics Hypertension - physiopathology Kidney Cortex - metabolism Kidney Medulla - metabolism Rats Rats, Inbred BN Rats, Inbred Dahl Rats, Inbred WKY Reverse Transcriptase Polymerase Chain Reaction Sodium Chloride, Dietary - administration & dosage Sodium Chloride, Dietary - toxicity Synteny
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Beschreibung
Zusammenfassung:	Previously, we found that transferring 6.1 Mb of salt-sensitive (SS) chromosome 12 (13.4–19.5 Mb) onto the consomic SS-12 background significantly elevated mean arterial pressure in response to an 8% NaCl diet (178±7 versus 144±2 mm Hg; P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.114.03550