Structure-Based Discovery of Natural-Product-like TNF-α Inhibitors

Small but effective: Two natural‐product‐like inhibitors of tumor necrosis factor α (TNF‐α; represented in green in the picture) have been identified using structure‐based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF‐α by a small molecule, and display potency comparable to that of the strongest TNF‐α inhibitor reported to date.