Role of serum cholesterol and statin use in the risk of prostate cancer detection and tumor aggressiveness

Role of serum cholesterol and statin use in the risk of prostate cancer detection and tumor aggressiveness

The aim of this study was to analyze the relationship between statin use along with serum cholesterol levels and prostate cancer (PCa) detection and aggressiveness. Statin users of three years or more and serum cholesterol levels (SC) were assessed in 2408 men scheduled for prostate biopsy. SC was c...

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Veröffentlicht in:International journal of molecular sciences 2014-08, Vol.15 (8), p.13615-13623
Hauptverfasser: Morote, Juan, Celma, Anna, Planas, Jacques, Placer, José, de Torres, Inés, Olivan, Mireia, Carles, Juan, Reventós, Jaume, Doll, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Cardiovascular Diseases - prevention & control
Cholesterol
Cholesterol - blood
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Logistic Models
Male
Medical diagnosis
Medical prognosis
Middle Aged
Neoplasm Staging
Odds Ratio
Prostate cancer
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
Risk Factors
Statins
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Zusammenfassung:The aim of this study was to analyze the relationship between statin use along with serum cholesterol levels and prostate cancer (PCa) detection and aggressiveness. Statin users of three years or more and serum cholesterol levels (SC) were assessed in 2408 men scheduled for prostate biopsy. SC was classified as normal (NSC: 200 mg/dL). High-grade PCa (HGPCa) was considered if the Gleason score was greater than 7. Statin users comprised 30.9% of those studied. The PCa detection rate was 31.2% of men on statins and 37% of non-statin users (p
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms150813615