Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity
Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An ac...
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| Veröffentlicht in: | Nano letters 2014-03, Vol.14 (3), p.1472-1476 |
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| container_title | Nano letters |
| container_volume | 14 |
| creator | Chu, Kevin S Finniss, Mathew C Schorzman, Allison N Kuijer, Jennifer L Luft, J. Christopher Bowerman, Charles J Napier, Mary E Haroon, Zishan A Zamboni, William C DeSimone, Joseph M |
| description | Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy. |
| doi_str_mv | 10.1021/nl4046558 |
| format | Article |
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Technologies ; Mice ; Nanocrystalline materials ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Nanoscale materials and structures: fabrication and characterization ; Neoplasms - drug therapy ; Neoplasms - pathology ; Others ; Physics ; Prodrugs - chemistry ; Prodrugs - pharmacology ; Replication ; Taxoids - chemistry ; Taxoids - pharmacology ; Toxicity ; Tumors ; Various methods and equipments ; Wettability ; Xenograft Model Antitumor Assays</subject><ispartof>Nano letters, 2014-03, Vol.14 (3), p.1472-1476</ispartof><rights>Copyright © 2014 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><rights>XXXX American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a468t-901032b42b3c42c63bf08230058ff646dad47d2e1233677abf78f064e5ae95533</citedby><cites>FETCH-LOGICAL-a468t-901032b42b3c42c63bf08230058ff646dad47d2e1233677abf78f064e5ae95533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/nl4046558$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/nl4046558$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28363034$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24552251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chu, Kevin S</creatorcontrib><creatorcontrib>Finniss, Mathew C</creatorcontrib><creatorcontrib>Schorzman, Allison N</creatorcontrib><creatorcontrib>Kuijer, Jennifer L</creatorcontrib><creatorcontrib>Luft, J. Christopher</creatorcontrib><creatorcontrib>Bowerman, Charles J</creatorcontrib><creatorcontrib>Napier, Mary E</creatorcontrib><creatorcontrib>Haroon, Zishan A</creatorcontrib><creatorcontrib>Zamboni, William C</creatorcontrib><creatorcontrib>DeSimone, Joseph M</creatorcontrib><title>Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity</title><title>Nano letters</title><addtitle>Nano Lett</addtitle><description>Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. 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Christopher</creator><creator>Bowerman, Charles J</creator><creator>Napier, Mary E</creator><creator>Haroon, Zishan A</creator><creator>Zamboni, William C</creator><creator>DeSimone, Joseph M</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20140312</creationdate><title>Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity</title><author>Chu, Kevin S ; Finniss, Mathew C ; Schorzman, Allison N ; Kuijer, Jennifer L ; Luft, J. 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| ispartof | Nano letters, 2014-03, Vol.14 (3), p.1472-1476 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Biological and medical sciences Biotechnology Chemical compounds Chemical synthesis methods Cross-disciplinary physics: materials science rheology Drug Carriers - chemistry Drug Carriers - pharmacology Drugs Effectiveness Ethers Exact sciences and technology Fundamental and applied biological sciences. Psychology Humans Materials science Methods of nanofabrication Methods. Procedures. Technologies Mice Nanocrystalline materials Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Nanoscale materials and structures: fabrication and characterization Neoplasms - drug therapy Neoplasms - pathology Others Physics Prodrugs - chemistry Prodrugs - pharmacology Replication Taxoids - chemistry Taxoids - pharmacology Toxicity Tumors Various methods and equipments Wettability Xenograft Model Antitumor Assays |
| title | Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity |
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