Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity

Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An ac...

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Veröffentlicht in:	Nano letters 2014-03, Vol.14 (3), p.1472-1476
Hauptverfasser:	Chu, Kevin S, Finniss, Mathew C, Schorzman, Allison N, Kuijer, Jennifer L, Luft, J. Christopher, Bowerman, Charles J, Napier, Mary E, Haroon, Zishan A, Zamboni, William C, DeSimone, Joseph M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Chemical compounds Chemical synthesis methods Cross-disciplinary physics: materials science rheology Drug Carriers - chemistry Drug Carriers - pharmacology Drugs Effectiveness Ethers Exact sciences and technology Fundamental and applied biological sciences. Psychology Humans Materials science Methods of nanofabrication Methods. Procedures. Technologies Mice Nanocrystalline materials Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Nanoscale materials and structures: fabrication and characterization Neoplasms - drug therapy Neoplasms - pathology Others Physics Prodrugs - chemistry Prodrugs - pharmacology Replication Taxoids - chemistry Taxoids - pharmacology Toxicity Tumors Various methods and equipments Wettability Xenograft Model Antitumor Assays
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Zusammenfassung:	Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl4046558