Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme

Radical control: A single glutamate residue (E287) in the coenzyme B12‐dependent ethanolamine ammonia lyase is pivotal to generating high‐energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2013-09, Vol.14 (13), p.1529-1533
Hauptverfasser:	Chen, Zhi-Gang, Ziętek, Monika A, Russell, Henry J., Tait, Shirley, Hay, Sam, Jones, Alex R., Scrutton, Nigel S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cobamides - metabolism coenzyme B12 Communications electrostatics enzymes Ethanolamine Ammonia-Lyase - chemistry Ethanolamine Ammonia-Lyase - metabolism Free Radicals - chemistry Free Radicals - metabolism Models, Molecular protein dynamics radicals Static Electricity Thermodynamics
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Beschreibung
Zusammenfassung:	Radical control: A single glutamate residue (E287) in the coenzyme B12‐dependent ethanolamine ammonia lyase is pivotal to generating high‐energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical intermediates towards the desired end by preventing side reactions.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201300420