Phenotype and functions of memory Tfh cells in human blood

Phenotype and functions of memory Tfh cells in human blood

Highlights • CXCR5+ CD4+ T cells represent a circulating memory compartment of Tfh lineage cells. • Blood memory Tfh cells are composed of phenotypically and functionally distinct subsets. • A proposed 3D approach defines nine blood memory Tfh subsets.

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Bibliographische Detailangaben
Veröffentlicht in:Trends in immunology 2014-09, Vol.35 (9), p.436-442
Hauptverfasser: Schmitt, Nathalie, Bentebibel, Salah-Eddine, Ueno, Hideki
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Antigens
Autoimmune diseases
Autoimmune Diseases - immunology
Biology
Blood Cells - immunology
Blood Circulation
Genotype & phenotype
human blood
Humans
Hypotheses
Immune system
Immunologic Memory
Immunophenotyping - methods
Influenza
Lymphocytes
Receptors, CXCR5 - metabolism
Rodents
Studies
subsets
T follicular helper cells
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Helper-Inducer - immunology
Vaccines
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Beschreibung
Zusammenfassung:Highlights • CXCR5+ CD4+ T cells represent a circulating memory compartment of Tfh lineage cells. • Blood memory Tfh cells are composed of phenotypically and functionally distinct subsets. • A proposed 3D approach defines nine blood memory Tfh subsets.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2014.06.002