Significance of blood analysis in hemophiliacs co-infected with human immunodeficiency virus and hepatitis viruses

AIM： To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs. METHODS： We have analyzed the immunological, liver function and cirrhosis markers in a cohort of hemophiliacs co-infected with human immunodeficiency virus （HIV） and hepatitis viruses. RESULTS： There was no difference in immunological markers among co-infected patients and patients infected with HIV only and those co-infected with one or more hepatitis virus. Although liver function and cirrhosis markers remained within a normal range, there was a worsening trend in all patients co-infected with hepatitis virus C （HCV）, which was further exacerbated in the presence of additional infection with hepatitis virus B （HBV）. CONCLUSION： Co-infection with HIV, HBV and HCV leads to worsening of hyaluronic acid and liver function markers. Increases in serum hyaluronic acid may be suggestive of a predisposition to liver diseases.