Comparative Study of Radionuclide Uptake Levels between Primary and Metastatic Bone Tumors

Study on 95 patients to compare radionuclide uptake levels in patients undergoing bone scintigraphy at a Nuclear Medicine Unit has been performed quantitatively using Image J software. Patients were administered with activity ranging from 0.555 to 1.110 MBq depending on their body weight, and their...

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Veröffentlicht in:World journal of nuclear medicine 2014-01, Vol.13 (1), p.50-55
Hauptverfasser: Huguette, Yigbedeck, Kwame, Kyere, Kojo, Wilson, Francis, Hasford, Kwabla, Sosu, Otoe, Ankrah
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Sprache:eng
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Zusammenfassung:Study on 95 patients to compare radionuclide uptake levels in patients undergoing bone scintigraphy at a Nuclear Medicine Unit has been performed quantitatively using Image J software. Patients were administered with activity ranging from 0.555 to 1.110 MBq depending on their body weight, and their whole-body bone scans obtained with an installed e.cam single-photon emission computed tomography system. Matrix size of 256 × 1024 was used in acquiring the scintigrams. Quantitative analyses performed with installed Image J software revealed higher radionuclide uptake levels in metastatic tumors compared with primary tumors for all selected skeletal parts. Average normalized count of activity in metastatic tumors was 37.117 ± 27.740 cts/mm 2 /MBq and its corresponding uptake in primary tumors was 23.035 ± 19.542 cts/mm 2 /MBq. The relative higher uptake in metastatic tumors over primary tumors could be attributed to higher osteoblastic activity and blood flow in metastatic tumors.
ISSN:1450-1147
1607-3312
DOI:10.4103/1450-1147.138575