Effects of high mobility group protein box 1 and toll like receptor 4 pathway on warts caused by human papillomavirus

Accumulative evidence has demonstrated that inflammation has an important role in human papillomavirus (HPV) oncogenicity. However, the effects of high mobility group protein box 1 (HMGB1)-toll like receptor 4 (TLR4) signaling pathway associated inflammation on epidermal warts caused by HPV remain u...

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Veröffentlicht in:	Molecular medicine reports 2014-10, Vol.10 (4), p.1765-1771
Hauptverfasser:	WENG, HUI, LIU, HONGBO, DENG, YUNHUA, XIE, YUYAN, SHEN, GUANXIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cell Nucleus - metabolism Cellular proteins Condyloma acuminatum Correlation analysis Extracellular Space - metabolism Health aspects high mobility group protein box 1 High mobility group proteins HMGB1 protein HMGB1 Protein - metabolism Human papillomavirus Humans Immunoglobulins Immunohistochemistry Inflammation Membranes Mobility nuclear factor-κB Nuclei Papillomaviridae - pathogenicity Papillomaviruses Physiological aspects Proteins Signal transduction Skin TLR4 protein toll like receptor 4 Toll-Like Receptor 4 - metabolism Toll-like receptors Transcription Factor RelA - metabolism Tumors Variance analysis verruca vulgaris Warts Warts - metabolism Warts - pathology
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Zusammenfassung:	Accumulative evidence has demonstrated that inflammation has an important role in human papillomavirus (HPV) oncogenicity. However, the effects of high mobility group protein box 1 (HMGB1)-toll like receptor 4 (TLR4) signaling pathway associated inflammation on epidermal warts caused by HPV remain unclear. The present study investigated the HMGB1, TLR4 and nuclear factor-κB p65 expression in condyloma acuminatum (CA) and verruca vulgaris (VV). Immunohistochemistry and western blot analysis revealed that p65 expression in epithelial nuclei in VV and CA was significantly higher than in normal skin (NS) (P
ISSN:	1791-2997 1791-3004
DOI:	10.3892/mmr.2014.2477