Refractory Hypertension: Determination of Prevalence, Risk Factors, and Comorbidities in a Large, Population-Based Cohort

Refractory Hypertension: Determination of Prevalence, Risk Factors, and Comorbidities in a Large, Population-Based Cohort

Refractory hypertension is an extreme phenotype of antihypertensive treatment failure. Participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, a large (n=30 239), population-based cohort were evaluated to determine the prevalence of refractory hypertension and as...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-03, Vol.63 (3), p.451-458
Hauptverfasser: Calhoun, David A., Booth, John N., Oparil, Suzanne, Irvin, Marguerite R., Shimbo, Daichi, Lackland, Daniel T., Howard, George, Safford, Monika M., Muntner, Paul
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Antihypertensive Agents - therapeutic use
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Comorbidity
Coronary Artery Disease - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Humans
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - physiopathology
Male
Medical sciences
Population Surveillance
Prevalence
Risk Factors
Stroke - epidemiology
Treatment Failure
United States - epidemiology
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Zusammenfassung:Refractory hypertension is an extreme phenotype of antihypertensive treatment failure. Participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, a large (n=30 239), population-based cohort were evaluated to determine the prevalence of refractory hypertension and associated cardiovascular risk factors and comorbidities. Refractory hypertension was defined as uncontrolled blood pressure (systolic/diastolic, ≥140/90 mm Hg) on ≥5 antihypertensive drug classes. Participants with resistant hypertension (systolic/diastolic, ≥140/90 mm Hg on ≥3 or
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.113.02026