Stress and neurodevelopmental processes in the emergence of psychosis

Highlights ► We review the evidence supporting associations between psychosocial stress and psychosis. ► We discuss the possible role of biological stress systems, particularly the hypothalamic-pituitary-adrenal (HPA) axis, in the etiology of psychosis. ► We review the findings of structural and fun...

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Veröffentlicht in:	Neuroscience 2013-09, Vol.249, p.172-191
Hauptverfasser:	Holtzman, C.W, Trotman, H.D, Goulding, S.M, Ryan, A.T, MacDonald, A.N, Shapiro, D.I, Brasfield, J.L, Walker, E.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescent Development - physiology Animals Biological and medical sciences Brain - growth & development Brain - metabolism brain development clinical high risk Fundamental and applied biological sciences. Psychology Humans hypothalamic–pituitary–adrenal (HPA) axis Hypothalamo-Hypophyseal System - metabolism Neurology Pituitary-Adrenal System - metabolism prodrome psychosis Psychotic Disorders - metabolism Psychotic Disorders - psychology stress Stress, Psychological - metabolism Stress, Psychological - psychology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► We review the evidence supporting associations between psychosocial stress and psychosis. ► We discuss the possible role of biological stress systems, particularly the hypothalamic-pituitary-adrenal (HPA) axis, in the etiology of psychosis. ► We review the findings of structural and functional brain abnormalities associated with psychosis. ► We posit potential neural mechanisms contributing to the pathogenesis of psychotic disorders.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.017