Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer

Background: Protein phosphatase 2A (PP2A) is a tumour suppressor frequently inactivated in human cancer and its tyrosine-307 phosphorylation has been reported as a molecular inhibitory mechanism. Methods: Expression of phosphorylated PP2A (p-PP2A) was evaluated in 250 metastatic colorectal cancer (C...

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Veröffentlicht in:	British journal of cancer 2014-08, Vol.111 (4), p.756-762
Hauptverfasser:	Cristóbal, I, Manso, R, Rincón, R, Caramés, C, Zazo, S, del Pulgar, T G, Cebrián, A, Madoz-Gúrpide, J, Rojo, F, García-Foncillas, J
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2422 692/699/67/1504/1885 692/699/67/322 Aged Alzheimer's disease Biological and medical sciences Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Colorectal cancer Colorectal Neoplasms - enzymology Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Confidence intervals Drug Resistance Epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Kaplan-Meier Estimate Kinases Liver Neoplasms - enzymology Liver Neoplasms - mortality Liver Neoplasms - secondary Male Medical prognosis Medical sciences Metastasis Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Multivariate Analysis Oncology Phosphatase Phosphoprotein Phosphatases - metabolism Phosphoproteins - metabolism Phosphorylation Proportional Hazards Models Protein Phosphatase 2C Protein Processing, Post-Translational Proteins Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	Background: Protein phosphatase 2A (PP2A) is a tumour suppressor frequently inactivated in human cancer and its tyrosine-307 phosphorylation has been reported as a molecular inhibitory mechanism. Methods: Expression of phosphorylated PP2A (p-PP2A) was evaluated in 250 metastatic colorectal cancer (CRC) patients. Chi-square, Kaplan–Meier and Cox analyses were used to determine correlations with clinical and molecular parameters and impact on clinical outcomes. Results: High p-PP2A levels were found in 17.2% cases and were associated with ECOG performance status ( P =0.001) and presence of synchronous metastasis at diagnosis ( P =0.035). This subgroup showed substantially worse overall survival (OS) (median OS, 6.0 vs 26.2 months, P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2014.376