Cerebellar and parkinsonian phenotypes in multiple system atrophy: similarities, differences and survival

Multiple system atrophy (MSA) is a neurodegenerative disease with two motor phenotypes: parkinsonian (MSA-P) and cerebellar (MSA-C). To elucidate whether in addition to the motor abnormalities there are other significant differences between these phenotypes, we performed a retrospective review of 10...

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Veröffentlicht in:Journal of Neural Transmission 2014-05, Vol.121 (5), p.507-512
Hauptverfasser: Roncevic, Dusan, Palma, Jose-Alberto, Martinez, Jose, Goulding, Niamh, Norcliffe-Kaufmann, Lucy, Kaufmann, Horacio
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Sprache:eng
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Zusammenfassung:Multiple system atrophy (MSA) is a neurodegenerative disease with two motor phenotypes: parkinsonian (MSA-P) and cerebellar (MSA-C). To elucidate whether in addition to the motor abnormalities there are other significant differences between these phenotypes, we performed a retrospective review of 100 patients (61 males, 39 females) with a diagnosis of possible (12 %), or probable (88 %) MSA. Four patients eventually had post-mortem confirmation (i.e., definite MSA). Sixty percent were classified as having MSA-P and 40 % as MSA-C. MSA-C and MSA-P patients had similar male prevalence (60 %), age of onset (56 ± 9 years), and frequency of OH (69 %). Brain MRI abnormalities were more frequent in MSA-C patients ( p  
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-013-1133-7