Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers
The purpose of this study was to assess whether cytochrome P450 enzyme 2A6 ( CYP2A6 ) genotypes moderate the association between smoking and hypertension. In this study, 954 Chinese male current smokers from a community-based chronic disease screening project in Guangzhou were interviewed with a str...
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Veröffentlicht in: | Journal of human hypertension 2013-01, Vol.27 (1), p.24-30 |
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Sprache: | eng |
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Zusammenfassung: | The purpose of this study was to assess whether cytochrome P450 enzyme 2A6 (
CYP2A6
) genotypes moderate the association between smoking and hypertension. In this study, 954 Chinese male current smokers from a community-based chronic disease screening project in Guangzhou were interviewed with a structured questionnaire about socio-demographic status, smoking and other health-related behaviors. Blood was collected for DNA extraction and
CYP2A6
genotyping. Hypertension was defined according to 2007 ESH-ESC Practice Guidelines. A multivariate logistic regression was performed to examine the interaction between smoking quantity and
CYP2A6
genotypes on hypertension after adjusting for age, education level and other potential confounders. Multivariate analyses indicated that smoking more than 15 cigarettes per day significantly increased the risk of hypertension (odds ratio (OR)=1.59, 95% confidence interval (CI)=1.21–2.10) compared with smoking 1–15 cigarettes per day, and further suggested that smoking interacted with normal
CYP2A6
metabolizer genotype to increase the risk of hypertension. Smokers consuming more than 15 cigarettes per day with normal
CYP2A6
metabolizer genotypes had the highest risk of hypertension (OR=2.04, 95% CI=1.11–3.75) compared with those consuming 1–15 cigarettes per day with slower
CYP2A6
metabolizer genotypes. These findings demonstrated that smoking quantity was positively associated with hypertension and that
CYP2A6
genotypes may moderate this relationship. |
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ISSN: | 0950-9240 1476-5527 |
DOI: | 10.1038/jhh.2011.111 |