Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

Segmented filamentous bacteria drive the acquisition of the T H 17 phenotype in an antigen-specific manner; these findings begin to elucidate how gut-induced T H 17 cells can contribute to distal organ-specific autoimmune disease. T H 17 cell differentiation linked to intestinal bacteria Colonizatio...

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Veröffentlicht in:	Nature (London) 2014-06, Vol.510 (7503), p.152-156
Hauptverfasser:	Yang, Yi, Torchinsky, Miriam B., Gobert, Michael, Xiong, Huizhong, Xu, Mo, Linehan, Jonathan L., Alonzo, Francis, Ng, Charles, Chen, Alessandra, Lin, Xiyao, Sczesnak, Andrew, Liao, Jia-Jun, Torres, Victor J., Jenkins, Marc K., Lafaille, Juan J., Littman, Dan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/31 59 631/250/347 Animals Antigens, Bacterial - chemistry Antigens, Bacterial - immunology Bacterial Vaccines Cell Differentiation Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Gram-Positive Bacteria - chemistry Gram-Positive Bacteria - immunology Humanities and Social Sciences Hybridomas - immunology Immunity, Mucosal - immunology Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestine, Small - cytology Intestine, Small - immunology Intestines - cytology Intestines - immunology letter Listeria monocytogenes - immunology Mice multidisciplinary Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Receptors, Antigen, T-Cell - immunology Science Symbiosis Th17 Cells - cytology Th17 Cells - immunology
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