Nicotine exposure beginning in adolescence enhances the acquisition of methamphetamine self-administration, but not methamphetamine-primed reinstatement in male rats

Highlights • Nicotine exposure during adolescence increased METH intake in adulthood. • Nicotine exposure during adolescence did not affect METH seeking behavior. • Low (0.16 mg/kg) but not high (0.64 mg/kg) nicotine exposure increased METH intake.

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Veröffentlicht in:Drug and alcohol dependence 2014-09, Vol.142, p.341-344
Hauptverfasser: Pipkin, Joseph A, Kaplan, Graham J, Plant, Christopher P, Eaton, Shannon E, Gil, Susan M, Zavala, Arturo R, Crawford, Cynthia A
Format: Artikel
Sprache:eng
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Zusammenfassung:Highlights • Nicotine exposure during adolescence increased METH intake in adulthood. • Nicotine exposure during adolescence did not affect METH seeking behavior. • Low (0.16 mg/kg) but not high (0.64 mg/kg) nicotine exposure increased METH intake.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2014.06.029