The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer

The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer

Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatmen...

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Veröffentlicht in:British journal of cancer 2014-07, Vol.111 (3), p.452-460
Hauptverfasser: Kang, M H, Go, S-I, Song, H-N, Lee, A, Kim, S-H, Kang, J-H, Jeong, B-K, Kang, K M, Ling, H, Lee, G-W
Format: Artikel
Sprache:eng
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692/53/2422
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Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Clinical Study
Disease-Free Survival
Drug Resistance
Epidemiology
Female
Humans
Kaplan-Meier Estimate
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - immunology
Lung Neoplasms - mortality
Lymphocyte Count
Lymphocytes - immunology
Male
Medical sciences
Middle Aged
Molecular Medicine
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Multivariate Analysis
Neutrophils - immunology
Oncology
Platelet Count
Pneumology
Prognosis
Proportional Hazards Models
Retrospective Studies
Small Cell Lung Carcinoma - drug therapy
Small Cell Lung Carcinoma - immunology
Small Cell Lung Carcinoma - mortality
Treatment Outcome
Tumors
Tumors of the respiratory system and mediastinum
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Zusammenfassung:Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment. Methods: We retrospectively reviewed patients who were diagnosed with SCLC and treated with platinum-based chemotherapy between July 2006 and October 2013 in Gyeongsang National University Hospital Regional Cancer Center and Changwon Samsung Hospital. Results: In total, 187 patients were evaluated. Compared with low NLR (
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2014.317