Getting Syk: spleen tyrosine kinase as a therapeutic target

Highlights • Syk couples many immune recognition receptors to inflammatory responses. • Syk is a pro-survival factor for several hematological and non-hematological cancers. • Small-molecule inhibitors of Syk are under development for the treatment of both immune disorders and cancer.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2014-08, Vol.35 (8), p.414-422
1. Verfasser:	Geahlen, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science allergic asthma Animals fostamatinib Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - immunology Intracellular Signaling Peptides and Proteins - metabolism leukemia Molecular Targeted Therapy protein kinase inhibitor Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - immunology Protein-Tyrosine Kinases - metabolism rheumatoid arthritis Syk Kinase tyrosine phosphorylation
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Beschreibung
Zusammenfassung:	Highlights • Syk couples many immune recognition receptors to inflammatory responses. • Syk is a pro-survival factor for several hematological and non-hematological cancers. • Small-molecule inhibitors of Syk are under development for the treatment of both immune disorders and cancer.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2014.05.007