The neural rejuvenation hypothesis of cocaine addiction

Highlights • Addiction may be partly mediated by mechanisms normally involved in development. • Juvenile substrates of molecular or neural plasticity reemerge after cocaine exposure. • Rejuvenated neural circuits are highly plastic and mature during cocaine withdrawal. • This creates strong and dura...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2014-08, Vol.35 (8), p.374-383
Hauptverfasser:	Dong, Yan, Nestler, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	addiction Advanced Basic Science Animals cocaine Cocaine-Related Disorders - etiology Cocaine-Related Disorders - pathology CREB dendritic spine Humans Neuronal Plasticity - drug effects Neuronal Plasticity - physiology NMDA receptor silent synapse synaptic plasticity
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Beschreibung
Zusammenfassung:	Highlights • Addiction may be partly mediated by mechanisms normally involved in development. • Juvenile substrates of molecular or neural plasticity reemerge after cocaine exposure. • Rejuvenated neural circuits are highly plastic and mature during cocaine withdrawal. • This creates strong and durable maladaptive changes underlying addiction.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2014.05.005