Prefrontal cortical regulation of fear learning

Prefrontal cortical regulation of fear learning

Highlights • Prefrontal cortex is necessary for the initial learning of complex fear associations. • Trace and contextual fear paradigms offer insight into cortical control of fear learning. • Emerging evidence suggests prefrontal cortex may modulate standard fear conditioning. • We review recent fi...

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Veröffentlicht in:Trends in neurosciences (Regular ed.) 2014-08, Vol.37 (8), p.455-464
Hauptverfasser: Gilmartin, Marieke R, Balderston, Nicholas L, Helmstetter, Fred J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anxiety
awareness
Brain
Fear
fear conditioning
fMRI
Humans
Information processing
Learning
Learning - physiology
Memory
Neurobiology
Neurology
Neurosciences
PFC
Prefrontal Cortex - physiology
prelimbic
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Beschreibung
Zusammenfassung:Highlights • Prefrontal cortex is necessary for the initial learning of complex fear associations. • Trace and contextual fear paradigms offer insight into cortical control of fear learning. • Emerging evidence suggests prefrontal cortex may modulate standard fear conditioning. • We review recent findings of an expanded role for prefrontal cortex in fear regulation.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2014.05.004