NAD+ and sirtuins in aging and disease

NAD+ and sirtuins in aging and disease

Highlights • NAD+ plays a key role in regulating metabolism and circadian rhythm through sirtuins. • NAD+ becomes limiting during aging, affecting sirtuins’ activities. • NAD+ decline is likely to be due to a NAD+ biosynthesis defect and increased depletion. • Supplementing key NAD+ intermediates ca...

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Veröffentlicht in:Trends in cell biology 2014-08, Vol.24 (8), p.464-471
Hauptverfasser: Imai, Shin-ichiro, Guarente, Leonard
Format: Artikel
Sprache:eng
Schlagworte:
Aging - metabolism
Animals
Circadian Rhythm
Disease
Humans
Mitochondria - metabolism
NAD
NAD - metabolism
nicotinamide mononucleotide
nicotinamide phosphoribosyltransferase
nicotinamide riboside
Pathology
poly-ADP-ribose polymerases
sirtuins
Sirtuins - metabolism
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Zusammenfassung:Highlights • NAD+ plays a key role in regulating metabolism and circadian rhythm through sirtuins. • NAD+ becomes limiting during aging, affecting sirtuins’ activities. • NAD+ decline is likely to be due to a NAD+ biosynthesis defect and increased depletion. • Supplementing key NAD+ intermediates can restore NAD+ levels and ameliorate age-associated pathophysiologies.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2014.04.002