Patterns of nodal metastasis and prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinoma

Background The current American Joint Committee on Cancer (AJCC) staging system may not accurately reflect survival in patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (SCC). The purpose of this study was to develop a system that more precisely predicts surviva...

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Veröffentlicht in:	Head & neck 2014-09, Vol.36 (9), p.1233-1240
Hauptverfasser:	Spector, Matthew E., Gallagher, K. Kelly, Bellile, Emily, Chinn, Steven B., Ibrahim, Mohannad, Byrd, Serena, Chanowski, Eric J., Walline, Heather M., Moyer, Jeffrey S., Prince, Mark E., Wolf, Gregory T., Bradford, Carol R., McHugh, Jonathan B., Cordell, Kitrina, Carey, Thomas, Worden, Francis P., Eisbruch, Avraham, Chepeha, Douglas B.
Format:	Artikel
Sprache:	eng
Schlagworte:	American Joint Committee on Cancer Staging System Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - virology Cervical cancer Cohort Studies Female Human papillomavirus Humans Lymph Nodes - pathology Lymphatic Metastasis Male matted nodes Medical prognosis Metastasis Middle Aged Neoplasm Staging - methods nodal metastasis Oropharyngeal Neoplasms - mortality Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - virology oropharyngeal squamous cell carcinoma Papillomavirus Infections - mortality Papillomavirus Infections - pathology Prognosis Survival Rate
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Zusammenfassung:	Background The current American Joint Committee on Cancer (AJCC) staging system may not accurately reflect survival in patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (SCC). The purpose of this study was to develop a system that more precisely predicts survival. Methods CT scans from 156 patients who underwent chemoradiation for advanced‐stage oropharyngeal SCC with >2 years follow‐up were reviewed. We modeled patterns of nodal metastasis associated with different survival rates. We defined HPV+N1 as a single node
ISSN:	1043-3074 1097-0347
DOI:	10.1002/hed.23438