Diagnosis of antiphospholipid syndrome in routine clinical practice

The updated international consensus criteria for definite antiphospholipid syndrome (APS) are useful for scientific clinical studies. However, there remains a need for diagnostic criteria for routine clinical use. We audited the results of routine antiphospholipid antibodies (aPLs) in a cohort of 19...

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Veröffentlicht in:	Lupus 2013-01, Vol.22 (1), p.18-25
Hauptverfasser:	Gardiner, C, Hills, J, Machin, SJ, Cohen, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Anticardiolipin - blood Anticoagulants antiphospholipid antibodies antiphospholipid syndrome Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - diagnosis Antiphospholipid Syndrome - immunology beta 2-Glycoprotein I - immunology Biomarkers - blood cardiolipin Clinical medicine Clinics Data processing Female Gynecology Humans Immunoglobulin G Immunoglobulin M Linear Models Lupus Lupus Coagulation Inhibitor - blood Male Morbidity Obstetrics Predictive Value of Tests Pregnancy Pregnancy Complications - blood Pregnancy Complications - diagnosis Pregnancy Complications - immunology Retrospective Studies Serology Systematic review Thrombosis Thrombosis - blood Thrombosis - diagnosis Thrombosis - immunology
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Zusammenfassung:	The updated international consensus criteria for definite antiphospholipid syndrome (APS) are useful for scientific clinical studies. However, there remains a need for diagnostic criteria for routine clinical use. We audited the results of routine antiphospholipid antibodies (aPLs) in a cohort of 193 consecutive patients with aPL positivity-based testing for lupus anticoagulant (LA), IgG and IgM anticardiolipin (aCL) and anti-ß2glycoprotein-1 antibodies (aß2GPI). Medium/high-titre aCL/aβ2GPI was defined as >99th percentile. Low-titre aCL/aβ2GPI positivity (>95th
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203312460722