Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

The tumor suppressor protein prostate apoptosis response-4 (PAR-4) is silenced in a subset of human cancers and its down-regulation serves as a mechanism for cancer cell survival following chemotherapy. PAR-4 re-expression selectively causes apoptosis in cancer cells but how its pro-apoptotic functi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oncotarget 2014-05, Vol.5 (10), p.2988-2998
Hauptverfasser:	Treude, Fabian, Kappes, Ferdinand, Fahrenkamp, Dirk, Müller-Newen, Gerhard, Dajas-Bailador, Federico, Krämer, Oliver H, Lüscher, Bernhard, Hartkamp, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Apoptosis Regulatory Proteins - metabolism Caspase 8 - metabolism Cell Line, Tumor Fluorescent Antibody Technique Humans Microscopy, Confocal Mutagenesis, Site-Directed Neoplasms - metabolism Research Paper Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!