The proton-coupled folate transporter: physiological and pharmacological roles

The proton-coupled folate transporter: physiological and pharmacological roles

Highlights • PCFT is the mechanism of intestinal absorption of folates and antifolates. • Inactivating mutations of the PCFT gene result in hereditary folate malabsorption. • PCFT activity is enhanced within the acidic microclimate of solid tumors. • PCFT is a potential route for the selective deliv...

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Veröffentlicht in:Current opinion in pharmacology 2013-12, Vol.13 (6), p.875-880
Hauptverfasser: Zhao, Rongbao, Goldman, I David
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Membrane - metabolism
Folic Acid - metabolism
Humans
Internal Medicine
Intestine, Small - metabolism
Medical Education
Proton-Coupled Folate Transporter - metabolism
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Zusammenfassung:Highlights • PCFT is the mechanism of intestinal absorption of folates and antifolates. • Inactivating mutations of the PCFT gene result in hereditary folate malabsorption. • PCFT activity is enhanced within the acidic microclimate of solid tumors. • PCFT is a potential route for the selective delivery of antifolates to tumor cells. • PCFT plays a role in folate transport across the choroid plexus.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2013.09.011