Response inhibition in motor conversion disorder
ABSTRACT Conversion disorders (CDs) are unexplained neurological symptoms presumed to be related to a psychological issue. Studies focusing on conversion paralysis have suggested potential impairments in motor initiation or execution. Here we studied CD patients with aberrant or excessive motor move...
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| Veröffentlicht in: | Movement disorders 2013-05, Vol.28 (5), p.612-618 |
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| creator | Voon, Valerie Ekanayake, Vindhya Wiggs, Edythe Kranick, Sarah Ameli, Rezvan Harrison, Neil A. Hallett, Mark |
| description | ABSTRACT
Conversion disorders (CDs) are unexplained neurological symptoms presumed to be related to a psychological issue. Studies focusing on conversion paralysis have suggested potential impairments in motor initiation or execution. Here we studied CD patients with aberrant or excessive motor movements and focused on motor response inhibition. We also assessed cognitive measures in multiple domains. We compared 30 CD patients and 30 age‐, sex‐, and education‐matched healthy volunteers on a motor response inhibition task (go/no go), along with verbal motor response inhibition (color‐word interference) and measures of attention, sustained attention, processing speed, language, memory, visuospatial processing, and executive function including planning and verbal fluency. CD patients had greater impairments in commission errors on the go/no go task (P |
| doi_str_mv | 10.1002/mds.25435 |
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Conversion disorders (CDs) are unexplained neurological symptoms presumed to be related to a psychological issue. Studies focusing on conversion paralysis have suggested potential impairments in motor initiation or execution. Here we studied CD patients with aberrant or excessive motor movements and focused on motor response inhibition. We also assessed cognitive measures in multiple domains. We compared 30 CD patients and 30 age‐, sex‐, and education‐matched healthy volunteers on a motor response inhibition task (go/no go), along with verbal motor response inhibition (color‐word interference) and measures of attention, sustained attention, processing speed, language, memory, visuospatial processing, and executive function including planning and verbal fluency. CD patients had greater impairments in commission errors on the go/no go task (P < .001) compared with healthy volunteers, which remained significant after Bonferroni correction for multiple comparisons and after controlling for attention, sustained attention, depression, and anxiety. There were no significant differences in other cognitive measures. We highlight a specific deficit in motor response inhibition that may play a role in impaired inhibition of unwanted movement such as the excessive and aberrant movements seen in motor conversion. Patients with nonepileptic seizures, a different form of conversion disorder, are commonly reported to have lower IQ and multiple cognitive deficits. Our results point toward potential differences between conversion disorder subgroups. © 2013 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.25435</identifier><identifier>PMID: 23554084</identifier><identifier>CODEN: MOVDEA</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Case-Control Studies ; cognition ; Cognition Disorders - etiology ; conversion disorder ; Conversion Disorder - complications ; Conversion Disorder - psychology ; Female ; Humans ; Inhibition, Psychological ; Male ; Memory Disorders - etiology ; Middle Aged ; Movement disorders ; Movement Disorders - complications ; Movement Disorders - psychology ; Neuropsychological Tests ; psychogenic movement disorder ; Reaction Time ; response inhibition ; Verbal Learning - physiology</subject><ispartof>Movement disorders, 2013-05, Vol.28 (5), p.612-618</ispartof><rights>Copyright © 2013 Movement Disorder Society</rights><rights>Copyright © 2013 Movement Disorder Society.</rights><rights>2013 Disorder Society 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4815-ee6d41228e84dbfd1add50669ae8e3c42a957b9fd4ff4d93b4f36e436c4300cd3</citedby><cites>FETCH-LOGICAL-c4815-ee6d41228e84dbfd1add50669ae8e3c42a957b9fd4ff4d93b4f36e436c4300cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.25435$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.25435$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23554084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voon, Valerie</creatorcontrib><creatorcontrib>Ekanayake, Vindhya</creatorcontrib><creatorcontrib>Wiggs, Edythe</creatorcontrib><creatorcontrib>Kranick, Sarah</creatorcontrib><creatorcontrib>Ameli, Rezvan</creatorcontrib><creatorcontrib>Harrison, Neil A.</creatorcontrib><creatorcontrib>Hallett, Mark</creatorcontrib><title>Response inhibition in motor conversion disorder</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>ABSTRACT
Conversion disorders (CDs) are unexplained neurological symptoms presumed to be related to a psychological issue. Studies focusing on conversion paralysis have suggested potential impairments in motor initiation or execution. Here we studied CD patients with aberrant or excessive motor movements and focused on motor response inhibition. We also assessed cognitive measures in multiple domains. We compared 30 CD patients and 30 age‐, sex‐, and education‐matched healthy volunteers on a motor response inhibition task (go/no go), along with verbal motor response inhibition (color‐word interference) and measures of attention, sustained attention, processing speed, language, memory, visuospatial processing, and executive function including planning and verbal fluency. CD patients had greater impairments in commission errors on the go/no go task (P < .001) compared with healthy volunteers, which remained significant after Bonferroni correction for multiple comparisons and after controlling for attention, sustained attention, depression, and anxiety. There were no significant differences in other cognitive measures. We highlight a specific deficit in motor response inhibition that may play a role in impaired inhibition of unwanted movement such as the excessive and aberrant movements seen in motor conversion. Patients with nonepileptic seizures, a different form of conversion disorder, are commonly reported to have lower IQ and multiple cognitive deficits. Our results point toward potential differences between conversion disorder subgroups. © 2013 Movement Disorder Society</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>cognition</subject><subject>Cognition Disorders - etiology</subject><subject>conversion disorder</subject><subject>Conversion Disorder - complications</subject><subject>Conversion Disorder - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Inhibition, Psychological</subject><subject>Male</subject><subject>Memory Disorders - etiology</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Movement Disorders - complications</subject><subject>Movement Disorders - psychology</subject><subject>Neuropsychological Tests</subject><subject>psychogenic movement disorder</subject><subject>Reaction Time</subject><subject>response inhibition</subject><subject>Verbal Learning - physiology</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PGzEQhi1UBGnooX8AReqFHjaM1x_xXpDKRwGJUIkWcbS861kw7K5TewPl3-MQiAoSJ1v2M8-M_RLylcKYAuS7rY3jXHAm1siACkYzlYvJJzIApUTGqBKb5HOMtwCUCio3yGbOhOCg-IDABcaZ7yKOXHfjStc736XtqPW9D6PKd_cY4uLMuuiDxbBF1mvTRPzysg7J5c-jPwcn2dmv49ODH2dZxRUVGaK0nOa5QsVtWVtqrBUgZWFQIat4bgoxKYva8rrmtmAlr5lEzmTFGUBl2ZDsLb2zedmirbDrg2n0LLjWhEftjdNvbzp3o6_9veZQSMpFEuy8CIL_O8fY69bFCpvGdOjnUVMmGHAABgn99g699fPQpectKCiYkCAT9X1JVcHHGLBeDUNBL3LQKQf9nENit_-ffkW-fnwCdpfAg2vw8WOTnh7-flVmywoXe_y3qjDhTssJmwh9dX6szw_3YXpyMU2NngDH7aFV</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Voon, Valerie</creator><creator>Ekanayake, Vindhya</creator><creator>Wiggs, Edythe</creator><creator>Kranick, Sarah</creator><creator>Ameli, Rezvan</creator><creator>Harrison, Neil A.</creator><creator>Hallett, Mark</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201305</creationdate><title>Response inhibition in motor conversion disorder</title><author>Voon, Valerie ; Ekanayake, Vindhya ; Wiggs, Edythe ; Kranick, Sarah ; Ameli, Rezvan ; Harrison, Neil A. ; Hallett, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4815-ee6d41228e84dbfd1add50669ae8e3c42a957b9fd4ff4d93b4f36e436c4300cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>cognition</topic><topic>Cognition Disorders - etiology</topic><topic>conversion disorder</topic><topic>Conversion Disorder - complications</topic><topic>Conversion Disorder - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Inhibition, Psychological</topic><topic>Male</topic><topic>Memory Disorders - etiology</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Movement Disorders - complications</topic><topic>Movement Disorders - psychology</topic><topic>Neuropsychological Tests</topic><topic>psychogenic movement disorder</topic><topic>Reaction Time</topic><topic>response inhibition</topic><topic>Verbal Learning - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voon, Valerie</creatorcontrib><creatorcontrib>Ekanayake, Vindhya</creatorcontrib><creatorcontrib>Wiggs, Edythe</creatorcontrib><creatorcontrib>Kranick, Sarah</creatorcontrib><creatorcontrib>Ameli, Rezvan</creatorcontrib><creatorcontrib>Harrison, Neil A.</creatorcontrib><creatorcontrib>Hallett, Mark</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voon, Valerie</au><au>Ekanayake, Vindhya</au><au>Wiggs, Edythe</au><au>Kranick, Sarah</au><au>Ameli, Rezvan</au><au>Harrison, Neil A.</au><au>Hallett, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response inhibition in motor conversion disorder</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2013-05</date><risdate>2013</risdate><volume>28</volume><issue>5</issue><spage>612</spage><epage>618</epage><pages>612-618</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><coden>MOVDEA</coden><abstract>ABSTRACT
Conversion disorders (CDs) are unexplained neurological symptoms presumed to be related to a psychological issue. Studies focusing on conversion paralysis have suggested potential impairments in motor initiation or execution. Here we studied CD patients with aberrant or excessive motor movements and focused on motor response inhibition. We also assessed cognitive measures in multiple domains. We compared 30 CD patients and 30 age‐, sex‐, and education‐matched healthy volunteers on a motor response inhibition task (go/no go), along with verbal motor response inhibition (color‐word interference) and measures of attention, sustained attention, processing speed, language, memory, visuospatial processing, and executive function including planning and verbal fluency. CD patients had greater impairments in commission errors on the go/no go task (P < .001) compared with healthy volunteers, which remained significant after Bonferroni correction for multiple comparisons and after controlling for attention, sustained attention, depression, and anxiety. There were no significant differences in other cognitive measures. We highlight a specific deficit in motor response inhibition that may play a role in impaired inhibition of unwanted movement such as the excessive and aberrant movements seen in motor conversion. Patients with nonepileptic seizures, a different form of conversion disorder, are commonly reported to have lower IQ and multiple cognitive deficits. Our results point toward potential differences between conversion disorder subgroups. © 2013 Movement Disorder Society</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23554084</pmid><doi>10.1002/mds.25435</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Case-Control Studies cognition Cognition Disorders - etiology conversion disorder Conversion Disorder - complications Conversion Disorder - psychology Female Humans Inhibition, Psychological Male Memory Disorders - etiology Middle Aged Movement disorders Movement Disorders - complications Movement Disorders - psychology Neuropsychological Tests psychogenic movement disorder Reaction Time response inhibition Verbal Learning - physiology |
| title | Response inhibition in motor conversion disorder |
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