Adipose tissue mass and location affect circulating adiponectin levels
Aims/hypothesis Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels. Methods We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of...
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| creator | Turer, A. T. Khera, A. Ayers, C. R. Turer, C. B. Grundy, S. M. Vega, G. L. Scherer, P. E. |
| description | Aims/hypothesis
Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels.
Methods
We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of body composition among 2,820 participants from the Dallas Heart Study.
Results
Among both women and men, adiponectin levels were higher in whites than in either Hispanics or African-Americans (for women: median 9.99 μg/ml [25th,75th percentile 7.11, 13.77] vs 7.56 μg/ml [5.05, 9.98] vs 6.39 μg/ml [4.37, 9.41], respectively,
p
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| doi_str_mv | 10.1007/s00125-011-2252-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4090928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>888339834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c564t-299cc43e2fab2f0faf4aad59387bb17f306dc181c1680550bf2bd6538c3b43f53</originalsourceid><addsrcrecordid>eNp1kV1LHDEUhkNpqavtD-hNGQrSq9F8ziQ3gkj9AKE3FnoXMplkG8kma86MoL_eLLvVVpBcBM77vOeDF6EvBB8RjPtjwJhQ0WJCWkoFbR_foQXhjLaYU_keLTZyS2T3ew_tA9xijJng3Ue0R0nfK9mpBTo_HcM6g2umADC7ZmUAGpPGJmZrppBTY7x3dmpsKHaOtZSWjdl4Uq2G1ER37yJ8Qh-8ieA-7_4D9Ov8x83ZZXv98-Lq7PS6taLjU0uVspYzR70ZqMfeeG7MKBST_TCQ3jPcjZZIYkknsRB48HQYO8GkZQNnXrADdLLtu56HlRutS1MxUa9LWJnyoLMJ-n8lhT96me81xworKmuD77sGJd_NDia9CmBdjCa5PIOWUjKmJOOV_PaKvM1zSfW6CvWKS9WTCpEtZEsGKM4_r0Kw3mSktxnpmpHeZKQfq-frvzc8O_6GUoHDHWDAmuiLSTbAC8cF6eqrHN1yUKW0dOVlw7enPwEb8Ksl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>887948971</pqid></control><display><type>article</type><title>Adipose tissue mass and location affect circulating adiponectin levels</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Turer, A. T. ; Khera, A. ; Ayers, C. R. ; Turer, C. B. ; Grundy, S. M. ; Vega, G. L. ; Scherer, P. E.</creator><creatorcontrib>Turer, A. T. ; Khera, A. ; Ayers, C. R. ; Turer, C. B. ; Grundy, S. M. ; Vega, G. L. ; Scherer, P. E.</creatorcontrib><description><![CDATA[Aims/hypothesis
Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels.
Methods
We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of body composition among 2,820 participants from the Dallas Heart Study.
Results
Among both women and men, adiponectin levels were higher in whites than in either Hispanics or African-Americans (for women: median 9.99 μg/ml [25th,75th percentile 7.11, 13.77] vs 7.56 μg/ml [5.05, 9.98] vs 6.39 μg/ml [4.37, 9.41], respectively,
p
< 0.0001; for men: 6.43 μg/ml [4.66, 9.19] vs 5.55 μg/ml [3.64, 7.50] vs 5.03 μg/ml [3.39, 7.28],
p
< 0.0001). In univariate analysis, each individual component of body mass was inversely associated with adiponectin. After multivariate analysis, adiponectin levels were found to be positively associated with lower extremity fat, whether expressed in absolute mass (for women:
β
= 0.055,
p
< 0.0001; for men:
β
= 0.061,
p
< 0.0001), or as a relative proportion (for women:
β
= 0.035,
p
< 0.0001; for men:
β
= 0.034,
p
< 0.0001). This association was consistent across ethnicities. Conversely, adiponectin was negatively correlated with truncal fat, both in absolute (for women:
β
= −0.039,
p
< 0.0001; for men:
β
= −0.044,
p
< 0.0001) and relative terms (for women:
β
= −0.027,
p
< 0.0001; for men
β
= −0.033,
p
< 0.0001). At the extreme of body mass, higher degrees of lower extremity and truncal adiposity were associated with higher levels of adiponectin.
Conclusions/interpretation
These data suggest that the location of adipose depots differentially influences circulating adiponectin concentrations—a finding observed across ethnicity and sex. Gross measures of body mass alone do not adequately account for adiponectin levels. This supports a role of adiponectin as a mediator of the positive effects of lower extremity adiposity on improvements in insulin sensitivity.]]></description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-011-2252-z</identifier><identifier>PMID: 21779869</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Absorptiometry, Photon ; Adiponectin - blood ; Adipose Tissue - metabolism ; Adiposity - physiology ; Adult ; African Americans ; Biological and medical sciences ; Body composition ; Body Composition - physiology ; Body fat ; Body Mass Index ; Body Weight - physiology ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Ethnicity ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Human Physiology ; Humans ; Insulin ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Minority & ethnic groups ; Multivariate Analysis ; Obesity ; Obesity - blood ; Obesity - metabolism ; Pediatrics ; Women ; Young Adult</subject><ispartof>Diabetologia, 2011-10, Vol.54 (10), p.2515-2524</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2011 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-299cc43e2fab2f0faf4aad59387bb17f306dc181c1680550bf2bd6538c3b43f53</citedby><cites>FETCH-LOGICAL-c564t-299cc43e2fab2f0faf4aad59387bb17f306dc181c1680550bf2bd6538c3b43f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00125-011-2252-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00125-011-2252-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,782,786,887,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24516161$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21779869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turer, A. T.</creatorcontrib><creatorcontrib>Khera, A.</creatorcontrib><creatorcontrib>Ayers, C. R.</creatorcontrib><creatorcontrib>Turer, C. B.</creatorcontrib><creatorcontrib>Grundy, S. M.</creatorcontrib><creatorcontrib>Vega, G. L.</creatorcontrib><creatorcontrib>Scherer, P. E.</creatorcontrib><title>Adipose tissue mass and location affect circulating adiponectin levels</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description><![CDATA[Aims/hypothesis
Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels.
Methods
We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of body composition among 2,820 participants from the Dallas Heart Study.
Results
Among both women and men, adiponectin levels were higher in whites than in either Hispanics or African-Americans (for women: median 9.99 μg/ml [25th,75th percentile 7.11, 13.77] vs 7.56 μg/ml [5.05, 9.98] vs 6.39 μg/ml [4.37, 9.41], respectively,
p
< 0.0001; for men: 6.43 μg/ml [4.66, 9.19] vs 5.55 μg/ml [3.64, 7.50] vs 5.03 μg/ml [3.39, 7.28],
p
< 0.0001). In univariate analysis, each individual component of body mass was inversely associated with adiponectin. After multivariate analysis, adiponectin levels were found to be positively associated with lower extremity fat, whether expressed in absolute mass (for women:
β
= 0.055,
p
< 0.0001; for men:
β
= 0.061,
p
< 0.0001), or as a relative proportion (for women:
β
= 0.035,
p
< 0.0001; for men:
β
= 0.034,
p
< 0.0001). This association was consistent across ethnicities. Conversely, adiponectin was negatively correlated with truncal fat, both in absolute (for women:
β
= −0.039,
p
< 0.0001; for men:
β
= −0.044,
p
< 0.0001) and relative terms (for women:
β
= −0.027,
p
< 0.0001; for men
β
= −0.033,
p
< 0.0001). At the extreme of body mass, higher degrees of lower extremity and truncal adiposity were associated with higher levels of adiponectin.
Conclusions/interpretation
These data suggest that the location of adipose depots differentially influences circulating adiponectin concentrations—a finding observed across ethnicity and sex. Gross measures of body mass alone do not adequately account for adiponectin levels. This supports a role of adiponectin as a mediator of the positive effects of lower extremity adiposity on improvements in insulin sensitivity.]]></description><subject>Absorptiometry, Photon</subject><subject>Adiponectin - blood</subject><subject>Adipose Tissue - metabolism</subject><subject>Adiposity - physiology</subject><subject>Adult</subject><subject>African Americans</subject><subject>Biological and medical sciences</subject><subject>Body composition</subject><subject>Body Composition - physiology</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Body Weight - physiology</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Ethnicity</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Multivariate Analysis</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - metabolism</subject><subject>Pediatrics</subject><subject>Women</subject><subject>Young Adult</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV1LHDEUhkNpqavtD-hNGQrSq9F8ziQ3gkj9AKE3FnoXMplkG8kma86MoL_eLLvVVpBcBM77vOeDF6EvBB8RjPtjwJhQ0WJCWkoFbR_foQXhjLaYU_keLTZyS2T3ew_tA9xijJng3Ue0R0nfK9mpBTo_HcM6g2umADC7ZmUAGpPGJmZrppBTY7x3dmpsKHaOtZSWjdl4Uq2G1ER37yJ8Qh-8ieA-7_4D9Ov8x83ZZXv98-Lq7PS6taLjU0uVspYzR70ZqMfeeG7MKBST_TCQ3jPcjZZIYkknsRB48HQYO8GkZQNnXrADdLLtu56HlRutS1MxUa9LWJnyoLMJ-n8lhT96me81xworKmuD77sGJd_NDia9CmBdjCa5PIOWUjKmJOOV_PaKvM1zSfW6CvWKS9WTCpEtZEsGKM4_r0Kw3mSktxnpmpHeZKQfq-frvzc8O_6GUoHDHWDAmuiLSTbAC8cF6eqrHN1yUKW0dOVlw7enPwEb8Ksl</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Turer, A. T.</creator><creator>Khera, A.</creator><creator>Ayers, C. R.</creator><creator>Turer, C. B.</creator><creator>Grundy, S. M.</creator><creator>Vega, G. L.</creator><creator>Scherer, P. E.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111001</creationdate><title>Adipose tissue mass and location affect circulating adiponectin levels</title><author>Turer, A. T. ; Khera, A. ; Ayers, C. R. ; Turer, C. B. ; Grundy, S. M. ; Vega, G. L. ; Scherer, P. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-299cc43e2fab2f0faf4aad59387bb17f306dc181c1680550bf2bd6538c3b43f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Absorptiometry, Photon</topic><topic>Adiponectin - blood</topic><topic>Adipose Tissue - metabolism</topic><topic>Adiposity - physiology</topic><topic>Adult</topic><topic>African Americans</topic><topic>Biological and medical sciences</topic><topic>Body composition</topic><topic>Body Composition - physiology</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Body Weight - physiology</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Ethnicity</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Multivariate Analysis</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - metabolism</topic><topic>Pediatrics</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turer, A. T.</creatorcontrib><creatorcontrib>Khera, A.</creatorcontrib><creatorcontrib>Ayers, C. R.</creatorcontrib><creatorcontrib>Turer, C. B.</creatorcontrib><creatorcontrib>Grundy, S. M.</creatorcontrib><creatorcontrib>Vega, G. L.</creatorcontrib><creatorcontrib>Scherer, P. E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turer, A. T.</au><au>Khera, A.</au><au>Ayers, C. R.</au><au>Turer, C. B.</au><au>Grundy, S. M.</au><au>Vega, G. L.</au><au>Scherer, P. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipose tissue mass and location affect circulating adiponectin levels</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>54</volume><issue>10</issue><spage>2515</spage><epage>2524</epage><pages>2515-2524</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract><![CDATA[Aims/hypothesis
Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels.
Methods
We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of body composition among 2,820 participants from the Dallas Heart Study.
Results
Among both women and men, adiponectin levels were higher in whites than in either Hispanics or African-Americans (for women: median 9.99 μg/ml [25th,75th percentile 7.11, 13.77] vs 7.56 μg/ml [5.05, 9.98] vs 6.39 μg/ml [4.37, 9.41], respectively,
p
< 0.0001; for men: 6.43 μg/ml [4.66, 9.19] vs 5.55 μg/ml [3.64, 7.50] vs 5.03 μg/ml [3.39, 7.28],
p
< 0.0001). In univariate analysis, each individual component of body mass was inversely associated with adiponectin. After multivariate analysis, adiponectin levels were found to be positively associated with lower extremity fat, whether expressed in absolute mass (for women:
β
= 0.055,
p
< 0.0001; for men:
β
= 0.061,
p
< 0.0001), or as a relative proportion (for women:
β
= 0.035,
p
< 0.0001; for men:
β
= 0.034,
p
< 0.0001). This association was consistent across ethnicities. Conversely, adiponectin was negatively correlated with truncal fat, both in absolute (for women:
β
= −0.039,
p
< 0.0001; for men:
β
= −0.044,
p
< 0.0001) and relative terms (for women:
β
= −0.027,
p
< 0.0001; for men
β
= −0.033,
p
< 0.0001). At the extreme of body mass, higher degrees of lower extremity and truncal adiposity were associated with higher levels of adiponectin.
Conclusions/interpretation
These data suggest that the location of adipose depots differentially influences circulating adiponectin concentrations—a finding observed across ethnicity and sex. Gross measures of body mass alone do not adequately account for adiponectin levels. This supports a role of adiponectin as a mediator of the positive effects of lower extremity adiposity on improvements in insulin sensitivity.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21779869</pmid><doi>10.1007/s00125-011-2252-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetologia, 2011-10, Vol.54 (10), p.2515-2524 |
| issn | 0012-186X 1432-0428 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4090928 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Absorptiometry, Photon Adiponectin - blood Adipose Tissue - metabolism Adiposity - physiology Adult African Americans Biological and medical sciences Body composition Body Composition - physiology Body fat Body Mass Index Body Weight - physiology Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ethnicity Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Human Physiology Humans Insulin Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Minority & ethnic groups Multivariate Analysis Obesity Obesity - blood Obesity - metabolism Pediatrics Women Young Adult |
| title | Adipose tissue mass and location affect circulating adiponectin levels |
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