Adipose tissue mass and location affect circulating adiponectin levels

Aims/hypothesis Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels. Methods We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of...

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Veröffentlicht in:	Diabetologia 2011-10, Vol.54 (10), p.2515-2524
Hauptverfasser:	Turer, A. T., Khera, A., Ayers, C. R., Turer, C. B., Grundy, S. M., Vega, G. L., Scherer, P. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Adiponectin - blood Adipose Tissue - metabolism Adiposity - physiology Adult African Americans Biological and medical sciences Body composition Body Composition - physiology Body fat Body Mass Index Body Weight - physiology Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ethnicity Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Human Physiology Humans Insulin Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Minority & ethnic groups Multivariate Analysis Obesity Obesity - blood Obesity - metabolism Pediatrics Women Young Adult
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Zusammenfassung:	Aims/hypothesis Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels. Methods We assessed plasma adiponectin concentrations and dual-energy X-ray absorptiometry (DEXA) measurements of body composition among 2,820 participants from the Dallas Heart Study. Results Among both women and men, adiponectin levels were higher in whites than in either Hispanics or African-Americans (for women: median 9.99 μg/ml [25th,75th percentile 7.11, 13.77] vs 7.56 μg/ml [5.05, 9.98] vs 6.39 μg/ml [4.37, 9.41], respectively, p
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-011-2252-z