MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway

Highlights • We examine changes of over 1000 miRNAs in human neural cells by Toxoplasma infection. • MiR-132 is highly upregulated by all three prototype Toxoplasma strains. • Dopamine receptor signaling is predicted to be the most regulated by miR-132. • Several members of dopamine receptor pathway...

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Veröffentlicht in:	Neuroscience 2014-05, Vol.268, p.128-138
Hauptverfasser:	Xiao, J, Li, Y, Prandovszky, E, Karuppagounder, S.S, Talbot, C.C, Dawson, V.L, Dawson, T.M, Yolken, R.H
Format:	Artikel
Sprache:	eng
Schlagworte:	alteration in expression Animals Biological and medical sciences Cell Line, Tumor Corpus Striatum - metabolism Dopamine - metabolism Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism dopamine receptor pathway Fundamental and applied biological sciences. Psychology Humans Hydroxyindoleacetic Acid - metabolism Mice MicroRNAs - metabolism miR-132 Monoamine Oxidase - metabolism mouse striatum Neuroectodermal Tumors, Primitive, Peripheral - metabolism Neurology Neurons - metabolism Receptors, Dopamine D1 - metabolism Receptors, Dopamine D5 - metabolism Serotonin - metabolism Signal Transduction Toxoplasma gondii Toxoplasmosis - metabolism Toxoplasmosis, Animal - metabolism Up-Regulation Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • We examine changes of over 1000 miRNAs in human neural cells by Toxoplasma infection. • MiR-132 is highly upregulated by all three prototype Toxoplasma strains. • Dopamine receptor signaling is predicted to be the most regulated by miR-132. • Several members of dopamine receptor pathway have been repressed in mice infection. • An elevation in the concentrations of dopamine and its metabolites occurred.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.03.015