G protein-coupled receptors and the regulation of autophagy

G protein-coupled receptors and the regulation of autophagy

Highlights • G protein-coupled receptors (GPCRs) can sense nutrients and regulate autophagy. • GPCRs regulate systemic autophagy by mediating the effects of hormones secreted in response to systemic nutrient fluctuations. • Downstream effectors of GPCRs that regulate autophagy include: cAMP, Ca2+ ,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in endocrinology and metabolism 2014-05, Vol.25 (5), p.274-282
Hauptverfasser: Wauson, Eric M, Dbouk, Hashem A, Ghosh, Anwesha B, Cobb, Melanie H
Format: Artikel
Sprache:eng
Schlagworte:
amino acid sensing GPCRs
AMPK
Animals
autophagy
Autophagy - physiology
Endocrinology & Metabolism
GLP-1 receptor
Humans
mTORC1
muscarinic receptor
Receptors, G-Protein-Coupled - metabolism
Signal Transduction - physiology
β-adrenergic receptor
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highlights • G protein-coupled receptors (GPCRs) can sense nutrients and regulate autophagy. • GPCRs regulate systemic autophagy by mediating the effects of hormones secreted in response to systemic nutrient fluctuations. • Downstream effectors of GPCRs that regulate autophagy include: cAMP, Ca2+ , IP3 , and PI3-kinase.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2014.03.006