Congenital transmission of multidrug-resistant tuberculosis

This article presents a case of multidrug-resistant tuberculosis (TB) in a Peruvian infant. His mother was diagnosed with disseminated TB, and treatment commenced 11 days postpartum. The infant was diagnosed with TB after 40 days and died at 2 months and 2 days of age. Congenital transmission of TB...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 2014-07, Vol.91 (1), p.92-95
Hauptverfasser:	Espiritu, Nora, Aguirre, Lino, Jave, Oswaldo, Sanchez, Luis, Kirwan, Daniela E, Gilman, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - therapeutic use Fatal Outcome Female Humans Infant Infectious Disease Transmission, Vertical Male Mycobacterium Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - pathogenicity Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis, Multidrug-Resistant - transmission
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Beschreibung
Zusammenfassung:	This article presents a case of multidrug-resistant tuberculosis (TB) in a Peruvian infant. His mother was diagnosed with disseminated TB, and treatment commenced 11 days postpartum. The infant was diagnosed with TB after 40 days and died at 2 months and 2 days of age. Congenital transmission of TB to the infant was suspected, because direct postpartum transmission was considered unlikely; also, thorough screening of contacts for TB was negative. Spoligotyping confirmed that both mother and baby were infected with identical strains of the Beijing family (SIT1).
ISSN:	0002-9637 1476-1645
DOI:	10.4269/ajtmh.13-0002