Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice

Highlights • 5xFAD mice are a familial Alzheimer model with profound neocortical layer 5 neurodegeneration. • Layer 5 neurons in 5xFAD mice are structurally intact up to 14 weeks. • Synaptic deficits are apparent in layer 5 neurons in young 5xFAD mice and appear before neurodegeneration. • Our data...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.254, p.152-159
Hauptverfasser:	Buskila, Y, Crowe, S.E, Ellis-Davies, G.C.R
Format:	Artikel
Sprache:	eng
Schlagworte:	5xFAD Alzheimer Disease - pathology Animals Biological and medical sciences Cerebral Cortex - pathology Cerebral Cortex - physiology Disease Models, Animal Fundamental and applied biological sciences. Psychology in vivo imaging Longitudinal Studies Mice Mice, Transgenic Neurology Neurons - pathology Neurons - physiology Organ Culture Techniques Synapses - pathology Synapses - physiology synaptic failure Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • 5xFAD mice are a familial Alzheimer model with profound neocortical layer 5 neurodegeneration. • Layer 5 neurons in 5xFAD mice are structurally intact up to 14 weeks. • Synaptic deficits are apparent in layer 5 neurons in young 5xFAD mice and appear before neurodegeneration. • Our data are consistent with the idea that synaptic loss is the first stage of neurodegeneration and eventual loss in FAD.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.016