Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study

Objective Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death in systemic sclerosis (SSc), facilitates earlier treatment. The objective of this study was to develop the first evidence-based detection algorithm for PAH in SSc. Methods In this cross-sectional, internat...

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Veröffentlicht in:	Annals of the rheumatic diseases 2014-07, Vol.73 (7), p.1340-1349
Hauptverfasser:	Coghlan, J Gerry, Denton, Christopher P, Grünig, Ekkehard, Bonderman, Diana, Distler, Oliver, Khanna, Dinesh, Müller-Ladner, Ulf, Pope, Janet E, Vonk, Madelon C, Doelberg, Martin, Chadha-Boreham, Harbajan, Heinzl, Harald, Rosenberg, Daniel M, McLaughlin, Vallerie V, Seibold, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Algorithms Breath Tests Cardiac Catheterization - methods Cardiology Cardiovascular disease Clinical and Epidemiological Research Clinical medicine Cross-Sectional Studies Early Diagnosis Echocardiography - methods Evidence-Based Medicine Familial Primary Pulmonary Hypertension Family medical history Female Heart Humans Hypertension Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - etiology Laboratories Logistic Models Lung diseases Male Medical prognosis Middle Aged Mortality Multivariate Analysis Nomograms Pharmaceuticals Population Pulmonary Diffusing Capacity Pulmonary Wedge Pressure Risk Assessment Scleroderma, Systemic - complications Sensitivity and Specificity Severity of Illness Index Studies Variables Velocity
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Beschreibung
Zusammenfassung:	Objective Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death in systemic sclerosis (SSc), facilitates earlier treatment. The objective of this study was to develop the first evidence-based detection algorithm for PAH in SSc. Methods In this cross-sectional, international study conducted in 62 experienced centres from North America, Europe and Asia, adults with SSc at increased risk of PAH (SSc for >3 years and predicted pulmonary diffusing capacity for carbon monoxide
ISSN:	0003-4967 1468-2060
DOI:	10.1136/annrheumdis-2013-203301