Sirtuins: guardians of mammalian healthspan

Highlights • Overexpression of the mammalian sirtuins SIRT1 and SIRT6 increases lifespan in mouse models. • Sirtuin activity is protective against a variety of age-associated diseases. • Sirtuins affect tumor initiation and maintenance via diverse mechanisms. • Small molecule interventions are emerg...

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Veröffentlicht in:	Trends in genetics 2014-07, Vol.30 (7), p.271-286
Hauptverfasser:	Giblin, William, Skinner, Mary E, Lombard, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	age-associated disease aging Aging - genetics Aging - metabolism Animals Genetic Association Studies Humans longevity Longevity - genetics Mammals Medical Education Mice mitochondria NAD Phenotype SIRT1 SIRT3 SIRT6 Sirtuins - genetics Sirtuins - metabolism
Online-Zugang:	Volltext
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