Sirtuins: guardians of mammalian healthspan

Sirtuins: guardians of mammalian healthspan

Highlights • Overexpression of the mammalian sirtuins SIRT1 and SIRT6 increases lifespan in mouse models. • Sirtuin activity is protective against a variety of age-associated diseases. • Sirtuins affect tumor initiation and maintenance via diverse mechanisms. • Small molecule interventions are emerg...

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Veröffentlicht in:Trends in genetics 2014-07, Vol.30 (7), p.271-286
Hauptverfasser: Giblin, William, Skinner, Mary E, Lombard, David B
Format: Artikel
Sprache:eng
Schlagworte:
age-associated disease
aging
Aging - genetics
Aging - metabolism
Animals
Genetic Association Studies
Humans
longevity
Longevity - genetics
Mammals
Medical Education
Mice
mitochondria
NAD
Phenotype
SIRT1
SIRT3
SIRT6
Sirtuins - genetics
Sirtuins - metabolism
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Beschreibung
Zusammenfassung:Highlights • Overexpression of the mammalian sirtuins SIRT1 and SIRT6 increases lifespan in mouse models. • Sirtuin activity is protective against a variety of age-associated diseases. • Sirtuins affect tumor initiation and maintenance via diverse mechanisms. • Small molecule interventions are emerging to modulate sirtuin functions in vivo.
ISSN:0168-9525
DOI:10.1016/j.tig.2014.04.007