Tumor Suppression: p53 Alters Immune Surveillance to Restrain Liver Cancer

The p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. A new study reveals that p53 also acts through a novel non-cell-autonomous mechanism, by stimulating the innate immune system to maintain tissue homeostasis and su...

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Veröffentlicht in:	Current biology 2013-06, Vol.23 (12), p.R527-R530
Hauptverfasser:	Raj, Nitin, Attardi, Laura D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis carcinogenesis cell cycle Cell Transformation, Neoplastic Cellular Senescence Hepatic Stellate Cells - metabolism homeostasis Humans innate immunity liver neoplasms Liver Neoplasms - metabolism Liver Neoplasms - pathology monitoring Tumor Suppressor Protein p53 - metabolism
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Beschreibung
Zusammenfassung:	The p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. A new study reveals that p53 also acts through a novel non-cell-autonomous mechanism, by stimulating the innate immune system to maintain tissue homeostasis and suppress tumorigenesis.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2013.04.076