Regulation of mTORC1 by amino acids

Highlights • Cellular amino acid levels tightly control the activity of the master growth regulator mTORC1. • The emergence of molecular details on how the mTORC1 pathway senses amino acids is an important advance in the field. • The amino acid sensing pathway is composed of several multicomponent c...

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Veröffentlicht in:	Trends in cell biology 2014-07, Vol.24 (7), p.400-406
Hauptverfasser:	Bar-Peled, Liron, Sabatini, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid sensing Amino Acids - metabolism Animals folliculin GATOR complex Humans Lysosomes - metabolism Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes - metabolism Pathology Rag GTPases Ragulator Signal Transduction TOR Serine-Threonine Kinases - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Cellular amino acid levels tightly control the activity of the master growth regulator mTORC1. • The emergence of molecular details on how the mTORC1 pathway senses amino acids is an important advance in the field. • The amino acid sensing pathway is composed of several multicomponent complexes that act in concert to convey changes in amino acid levels to mTORC1.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2014.03.003